dry eye — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3316	Fluorometholone	Fluoromethalone,Cortilet,Oxylone,Delmeson	Glucocorticoid Receptor
	Fluorometholone (Fluoromethalone) is a corticosteroid, most often used after laser-based refractive surgery. It is marketed under the brand names FML (Allergan) and Flarex (Alcon). Fluorometholone acetate ophthalmic susp...		Glucocorticoid Receptor
T3977	Lifitegrast	SHP-606,SAR 1118	Integrin
	Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.		Integrin
T33584	Namirotene	CBS 211A,Cbs 211 A	Others
	Namirotene (CBS 211A) is a protein biosynthesis inhibitor, a synthetic retinoic acid analog that is used in the study of corneal diseases, corneal ulcers and dry eye syndrome.		Others
T13571	JAK-IN-10		JAK
	JAK-IN-10 is a JAK inhibitor. JAK-IN-10 can be used for the research of dry eye disorders.		JAK
T7099	Gefarnate		Others
	Gefarnate is a synthetic compound used for the treatment of gastric ulcers,and also used in the treatment of dry eye syndrome.		Others
T67907	Nimucitinib		JAK
	Nimucitinib is a Janus kinase (JAK) inhibitor that can be used to treat dry eye and promote tear production.		JAK
T16732	Reproxalap	NS-2,ADX-102	Others
	Reproxalap (NS-2) covalently binds aldehydes including malondialdehyde and 4-hydroxynonenal. Reproxalap is a reactive aldehyde species sequestering agent for the treatment of the dry eye.		Others
T40867	Simpinicline	OC-02	AChE
	Simpinicline (OC-02) (OC-02) is a highly selective nicotinic acetylcholine receptor (nAChR) agonist that activates the trigeminal parasympathetic pathway and can be used to treat dry eye.		AChE
T7423	Diquafosol tetrasodium	INS365	P2Y Receptor
	Diquafosol Tetrasodium is a P2Y2 receptor agonist that stimulates the secretion of mucins from ocular tissues Diquafosol tetrasodium (INS365) improves tear film stability and visual function, as a topical treatment of dr...		P2Y Receptor
T71704	Navamepent	RX-10045	Others
	Navamepent (RX-10045) is an analog of resolvin E1 (a dietary-3 polyunsaturated fatty acid metabolite), which has potent anti-inflammatory activity that reduces corneal inflammation, epithelial damage, and accelerates cor...		Others
T32133	Icomucret	AL-12959,AL 12959,AL12959
	Icomucret can be used for the Treatment of Dry Eye.
T28496	R-932348 choline	R-932348,R 348,R 932348,R932348,R-348,R348
	R-932348 choline, a dual JAK/SYK inhibitor, is used potentially for treatment of dry eye disease.
T39293	Tivanisiran	SYL1001,Tivanisiran
	Tivanisiran (SYL1001) is a siRNA developed specifically to inhibit the expression of transient receptor potential vanilloid 1 (TRPV1) to explore its implications in dry eye disease research.
T76988	Tanfanercept
	Tanfanercept (HL036337), an anti-TNF-α monoclonal antibody, has shown efficacy in reducing corneal erosions in a dry eye (DE) mouse model [1] [2].
T82074	Immune cell migration-IN-1
	Immune cell migration-IN-1 (compound 2) serves as a potent inhibitor of immune cell migration, with potential research applications for mitigating conditions such as dry eye diseases, eczema dermatitis, and psoriasis [1]...
T79235	JAK-IN-30		JAK
	JAK-IN-30 (compound 31) is a water-soluble inhibitor of Janus kinases (JAKs), demonstrating inhibitory potency with half-maximal inhibitory concentration (IC50) values of 2 nM for JAK2, 15 nM for JAK1, 18 nM for JAK3, an...		JAK
T70346	TOP1362
	TOP1362 is a Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders. TOP1362 strongly inhibited the kinase targets p38α, Syk, Src, and Lck, bloc...
T82073	Immune cell migration-IN-2
	Immune cell migration-IN-2 is a potent inhibitor of immune cell migration, exhibiting an EC50 value of 13.5 nM in a T-cell adhesion assay. This compound is utilized in research pertaining to dry-eye and other retinal dis...